DIFFERENCE OF BREAST CANCER ESTROGEN RECEPTOR (ER) BETWEEN OBESE PRE-MENOPAUSE WOMEN AND OBESE POST-MENOPAUSE WOMEN

Viqi Vincentius Julio, Sindrawati Sindrawati, Fransiscus Arifin

Abstract


Background: One of the risk of breast cancer is Obesity (BMI > 23Kg/m2) related to estrogen production between pre-menopause and post-menopause.

Aim: To investigate the difference of breast cancer estrogen receptor (ER) in obese women based on menopausal status.

Methods: This study was retrospective cross-sectional from secondary data (Medical Records) from Poliklinik Onkologi Satu Atap (POSA) RSUD Dr. Soetomo (ICD-10 C50) from 2013-2017 with inclusion criteria was BMI >23Kg/m2. Data were analyzed using Chi-Square.

Results: There were 138 patient medical records collected which is 63 were obese pre-menopause and 75 were obese post-menopause. There were statistically a significant difference (p<0,05) based on Chi square test of breast cancer estrogen receptor for obese post-menopause women (66,7%) to obese pre-menopause (39,7%). Obese post-menopause women have 1,68 times greater risk factor to become estrogen receptor positive (ER+) compared to obese pre-menopause women. (PR = 1,68; 95% CI = 1,191-2,370)

Conclusion : There is a significant difference of breast cancer estrogen receptor in obese post-menopause women more frequent than obese pre-menopause women.


Keywords


Breast Cancer; Estrogen Receptors; Obese; Menopausal Status

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References


Breast cancer: prevention and control [Internet]. World Health Organization. 2018 [cited 20 April 2018]. Available from: http://www.who.int/cancer/detection/breastcancer/en/index1.html

Tao Z, Shi A, Lu C, Song T, Zhang Z, Zhao J. Breast Cancer: Epidemiology and Etiology.Cell Biochem Biophys. 2014;72(2):333-338.

Hamdy O. Obesity: Practice Essentials, Background, Pathophysiology [Internet]. Emedicine.medscape.com. 2018 [cited 20 April 2018]. Available from: https://emedicine.medscape.com/article/123702-overview#a5

Rose D, Vona-Davis L. Influence of obesity on breast cancer receptor status and prognosis. Expert Rev Anticancer Ther. 2009;9(8):1091-1101.

Hall J, Guyton A. Guyton and Hall textbook of medical physiology. 12th ed. Philadelphia, PA: Saunders/Elsevier; 2011. Chapter 81, Female Physiology Before Pregnancy and Female Hormones; p. 991-4, 999.

Biglia N, Peano E, Sgandurra P, Moggio G, Pecchio S, Maggiorotto F et al. Body mass index (BMI) and breast cancer: impact on tumor histopatologic features, cancer subtypes and recurrence rate in pre and postmenopausal women. Gynecol Endocrinol. 2012;29(3):263-267.

Crispo A, Montella M, Buono G, Grimaldi M, DAiuto M, Capasso I et al. Body weight and risk of molecular breast cancer subtypes among postmenopausal Mediterranean women. Curr Res in Trans Med. 2016;64(1):15-20.

Yanai A, Miyagawa Y, Murase K, Imamura M, Yagi T, Ichii S et al. Influence of body mass index on clinicopathological factors including estrogen receptor, progesterone receptor, and Ki67 expression levels in breast cancers. International Journal of Clinical Oncology. 2013;19(3):467-472.

Sahin S, Erdem G, Karatas F, Aytekin A, Sever A, Ozisik Y et al. The association between body mass index and immunohistochemical subtypes in breast cancer. The Breast. 2017;32:227-236.

Brief History of Breast Cancer [Internet]. Ncbi.nlm.nih.gov. 2014 [cited 16 April 2018]. Available from

Contr V, R. Basile J, Proia P. Sex steroid hormone receptors, their ligands, and nuclear and non-nuclear pathways. Molsci. 2015;2(3):297.

Simpson E, Brown K. Obesity and breast cancer: role of inflammation and aromatase. J Mol Endocrinol. 2013;51(3):T51-T59.

Berger N, Dannenberg A. Obesity, Inflammation and Cancer. Chapter 8 : Obesity, Inflamation, and Cancer. New York: Springer; 2013. p. 184-186.

Simpson E, Brown K. Obesity and breast cancer: role of inflammation and aromatase. J Mol Endocrinol. 2013;51(3):T51-T59.

Lizcano F, Guzmn G. Estrogen Deficiency and the Origin of Obesity during Menopause. BioMed Research International. 2014;2014:1-11.

Nattenmller C, Kriegsmann M, Sookthai D, Fortner R, Steffen A, Walter B et al. Obesity as risk factor for subtypes of breast cancer: results from a prospective cohort study. BMC Cancer. 2018;8.

Bandera E, Chandran U, Hong C, Troester M, Bethea T, Adams-Campbell L et al. Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium. Breast Cancer Research and Treatment. 2015;150(3):655-666.

Rad M, Torkmannejad Sabzevary M, Mohebbi Dehnavi Z. Association Between Menstrual Disorders and Obesity-Related Anthropometric Indices in Female High School Students: A Cross-Sectional Study. International Journal of School Health. 2018;5.




DOI: https://doi.org/10.33508/jwmj.v5i3.4853

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