Oksigen Hiperbarik (OHB) Menyembuhkan Sel Melalui Spesies Oksigen Reaktif (SOR)

Handi Suyono


In degenerative diseases, hypoxia is the fundamental mechanism. Hypoxia stimulates reactive oxygen species (ROS) production. ROS interacts with protein, lipid, DNA, and other cell’s components and cause damage. Hyperbaric oxygen (HBO) improves clinical outcomes but the exact mechanism is still debated. HBO reverses hypoxia state. HBO increases ROS production because of hyperoxia but it can heal the cell. HBO-induced ROS stimulates endogenous antioxidants, hypoxia-inducible factors, and heat shock proteins. ROS theoretically improves telomere length and telomerase activity. Superoxide is one of ROS which converted into hydrogen peroxide and it acts as signal transduction. ROS has positive outcomes in maintaining cell survival

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DOI: https://doi.org/10.33508/jwm.v4i2.1817