Pemakaian Nitroglycerin Intravena Invivo Sebagai Antidotum Efek Heparin
Abstract
Introduction: intravenous nitroglycerin, if given simultaneously with heparin, can obstruct the heparin's anticoagulant effect, but it still remains controversy. This statement underlies researcher to authenticate whether intravenous nitroglycerin can neutralize heparin
Aim: to find out if intravenous nitroglycerin can neutralize heparin
Method: this research is an in vivo experiment with a rabbit as the experimental subject at The Pharmacology Department of The Medical Faculty of The Airlangga University. The experimental subjects are divided into a control group and a treatment. The control group is only given a dose of heparin, while the treatment is given a dose of heparin and some doses of intravenous nitroglycerin. Each of this experimental subjects will be examined its activated clotting time (ACT) score with a hemochrone. The statistical test that will be used is the normality test with one sample kolmogorov smirnov test
Result: the administration of 3 mg/kg dose of intravenous glyceryl trinitrate after the administration of 3 mg/kg heparin can reduce the ACT value or neutralize the heparin's anticoagulant effect significantly with the value p= 0,001 (pc0,005). The group that receives 6 mg/kg glyceryl trinitrate, if compared to the prior ACT before the administration of 6 mg/kg glyceryl trinitrate, has a change with the value p= 0,001 (PO, 05). The group that receives 9 mg/kg glyceryl trinitrate, if compared to the prior ACT before the administration of 9 mg/kg glyceryl trinitrate, has a significant change with p=0,010 (P<0,005). If compared to the ACT control, it has a change with the value p= 0,010 (P<0,005). If compared to the that receives 3 mg/kg intravenous glyceryn trinitrate administration, it has a significant change with the value p= 0,026 (P<0,005). But, if it is compared to the group that receives 6 mg/kg intravenous glyceryn trinitrate administration, there is no significant change with the value p= 0,506 (p<0,005)
Conclusion: the administration of intravenous nitroglycerin can neutralize heparin in vivo. That means intravenous nitroglycerin have the quality as a heparin antidote. The statistical calculation states that increasing the dosage of intravenous nitroglycerin from 3 mg/kg to 9 mg/kg give a significant ACT's value decrease, while increasing the dosage of intravenous nitroglycerin from 3 mg/kg to 6 mg/kg give insignificant ACT's value decrease.
Aim: to find out if intravenous nitroglycerin can neutralize heparin
Method: this research is an in vivo experiment with a rabbit as the experimental subject at The Pharmacology Department of The Medical Faculty of The Airlangga University. The experimental subjects are divided into a control group and a treatment. The control group is only given a dose of heparin, while the treatment is given a dose of heparin and some doses of intravenous nitroglycerin. Each of this experimental subjects will be examined its activated clotting time (ACT) score with a hemochrone. The statistical test that will be used is the normality test with one sample kolmogorov smirnov test
Result: the administration of 3 mg/kg dose of intravenous glyceryl trinitrate after the administration of 3 mg/kg heparin can reduce the ACT value or neutralize the heparin's anticoagulant effect significantly with the value p= 0,001 (pc0,005). The group that receives 6 mg/kg glyceryl trinitrate, if compared to the prior ACT before the administration of 6 mg/kg glyceryl trinitrate, has a change with the value p= 0,001 (PO, 05). The group that receives 9 mg/kg glyceryl trinitrate, if compared to the prior ACT before the administration of 9 mg/kg glyceryl trinitrate, has a significant change with p=0,010 (P<0,005). If compared to the ACT control, it has a change with the value p= 0,010 (P<0,005). If compared to the that receives 3 mg/kg intravenous glyceryn trinitrate administration, it has a significant change with the value p= 0,026 (P<0,005). But, if it is compared to the group that receives 6 mg/kg intravenous glyceryn trinitrate administration, there is no significant change with the value p= 0,506 (p<0,005)
Conclusion: the administration of intravenous nitroglycerin can neutralize heparin in vivo. That means intravenous nitroglycerin have the quality as a heparin antidote. The statistical calculation states that increasing the dosage of intravenous nitroglycerin from 3 mg/kg to 9 mg/kg give a significant ACT's value decrease, while increasing the dosage of intravenous nitroglycerin from 3 mg/kg to 6 mg/kg give insignificant ACT's value decrease.
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PDFDOI: https://doi.org/10.33508/jwm.v4i2.1813
