Formulasi and Evaluasi Stabilitas Fisik Suspensi Ubi Cilembu (Ipomea batatas L.) dengan Suspending Agent CMC Na dan PGS Sebagai Antihiperkolesterol

Abstract

Drug which has small solubility in water is one of the problems that cause instability of pharmaceutical
preparations. One drug practically insoluble in water is cilembu (Ipomoea batatas L.). So cilembu (Ipomoea
batatas L.) made in form of suspension in order to produce stable preparations in liquid form. Making of the
suspension cannot be separated from the suspending agent. CMC Na (Carboxymethylcellulose Sodium) and
PGS (pulvis gummosus) is suspending agent which have been studied to produce a stable suspension.
Accordingly, this study was conducted to know the suspension evaluation stability cilembu (Ipomoea batatas L.)
with a suspending agent CMC Na and PGS as antihypercholesterol. Method of manufacture is dispersion
method. Evaluation of physical stability test was conducted on the organoleptic, homogeneity, pH, density,
viscosity, sedimentation volume, and redispersion. Data were analyzed with repeated measures and shelflife.
Evaluation of physical stability the suspension cilembu with a suspending agent CMC Na and PGS on
observations organoleptic, homogeneity, density and redispersion showed no difference, while the pH,
viscosity and sedimentation volume were not significant differences (p< 0.05) during 30 days of storage.

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