DIFFERENCES IN SCORING OF THORACIC PHOTOGRAPHS BETWEEN MDR-TB AND DS-TB PATIENTS WITH PULMONARY TUBERCULOSIS

Epriyanto Tridharmadi, Elisabeth Tri Wahyuni Widoretno, Paul L Tahalele, Belinda Peregrina M. Nahak

Abstract


Background: Tuberculosis (TB) is ranked as the second deadliest infectious disease in the world. There is a drastic increase in TB cases by 2023 with 92% of these cases being pulmonary TB infections. Thoracic photography is a standard examination performed to determine the development of tuberculosis disease through reviewing populations with TB risk factors, one of which is patients with MDR-TB (Multi-Drug Resistance) can result in increased opacity in the lower lung lobes with pulmonary, cavity, and parenchymal lesions. Thoracic photo scoring was performed to determine the severity of lesions in the thoracic photo images of TB patients with MDR (Multi-Drug Resistance) and DS (Drug-Sensitive).

Objective: to compare the scoring of thoracic photographs between of TB patients with MDR-TB and DS-TB.

Method: using observational analytic method with cross-sectional research design. The sampling technique used purposive sampling method through medical records with analysis using two tests, namely Wilcoxon and Mann-Whitney comparative test. Radiologic findings that we analyzed were infiltrate, consolidation, cavity, ground glass opacity, fibrosis, bronchiectasis, calcification, node, atelectasis, bullae, emphysema, and other nonlung parenchymal findings.

Results: The samples to be analyzed were 55 samples had completed anti-tuberculosis therapy in the 6th month and had thoracic photographs. The Wilcoxon Comparative Test on two paired groups showed a significant difference between the TB group with MDR (p=0.008) and DS (p=0.000). In the Mann-Whitney comparative test on two unpaired groups, there were no significant results either TB groups with MDR and DS (p=0.282). Scoring results in MDR-TB patients after therapy showed mild (3.70%), moderate (44.44%), severe (51.85%) categories. In DS-TB patients, showed mild (37.03%), moderate (48.15%), severe (14.81%) categories.

Conclusion: There is a significant difference between the severity of thoracic photographs in TB patients with MDR and without MDR (Drug-Sensitive).


Save to Mendeley


Keywords


Tuberculosis; Multi-Drug Resistance; Drug-Sensitive; Thoracic photo severity scoring

Full Text:

PDF

References


Rotimi Adigun ; Rahulkumar Singh. Tuberculosis. NCBI Bookshelf. 2023;

Ministry of Health RI. InfoDATIN - Data and Information Center of the Ministry of Health. Data and Information Center of the Ministry of Health. 2020. p. 1-10.

World Health Organization. Global Tuberculosis Report 2014. USA: World Health Organization; 2014. p. 1-147.

Technical Guidelines for Multi-drug Resistant Tuberculosis Holistic Control. Directorate General for Disease and Environmental Health Control. Jakarta: Ministry of Health Indonesia; 2014. p. 1-111.

Center for Tuberculosis Information and Data. Ministry of Health Indonesia; 2015. p. 1-7.

Reviono, Harsini IJ, Aphridasari J, Sutanto YS. Comparisons of clinical, radiological and smear conversion of multi-drug resistant patients with diabetes and without diabetes at the Dr. Moewardi Hospital, Solo. J Respirol Indones 2013;2:103-9.

Icksan AG, Maryastuti M. Characteristics of chest X-ray lesion in smear-negative TB patient with culture-positive vs. culture-negative in the Persahabatan Hospital, Jakarta. Bul Ilmiah Radiol 2012;2:80-90. [Indonesian Society of Radiology chapter Yogyakarta and Department of Radiology, University of Gajah Mada Faculty of Medicine, Yogyakarta].

Icksan AG. The Accuracy of CT Scan without Contrast Scoring System in the Diagnosis of Adult Pulmonary TB. Doctoral Dissertation of the PhD in Clinical Medicine. Yogyakarta: University of Gajah Mada Faculty of Medicine; 2014. p. 1-156

Icksan, Aziza Ghanie, et al. Chest X-ray findings comparison between multi-drug-resistant tuberculosis and drug-sensitive tuberculosis. Journal of natural science, biology, and medicine, 2018, 9.1: 42.

Aditama TY. National Action Plan of Programmatic Management Drug Resistance Tuberculosis Control Indonesia 2011-2014. Directorate General for Disease and Environmental Health Control. Jakarta: Ministry of Health Indonesia; 2011. p. 1-54

Deesuwan P, Autravisittikul O, Girapongsa L. Chest radiographic findings of multidrug resistant pulmonary tuberculosis in comparisons to drug-sensitive pulmonary tuberculosis in non-HIV patient. Region 4-5 Med J 2015;34:66-78.

Cha J, Lee HY, Lee KS, Koh WJ, Kwon OJ, Yi CA, et al. Radiological findings of extensively drug resistant pulmonary tuberculosis in non AIDS adults: Comparisons with findings of multidrug resistant and drug-sensitive tuberculosis. Korean J Radiol 2009;10:207-16.

Zahirifard S, Amiri MV, Karom MB, Mirsaeidi SM, Ehsanpour A, MasjediMR. The radiological spectrum of pulmonary multidrug-resistant tuberculosis In HIV-negative patients. Iran J Radiol 2013;1:161-6.

Ahuja SD, Ashkin D, Avendano M, Banerjee R, Bauer M, Bayona JN, et al. Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: An individual patient data meta-analysis of 9,153 patients. PLoS Med 2012;9:e1001300.

Prasad R. Multidrug and extensively drug-resistant tuberculosis management: Evidences and controversies. Lung India 2012;29:154-9.

Fitri L, Marlindawani J, Agnes Purba. Adherence to Taking Medication in Pulmonary Tuberculosis Patients. Journal of Public Health Sciences.




DOI: https://doi.org/10.33508/jwmj.v6i3.5759

Refbacks

  • There are currently no refbacks.