Stefanny Andrea Williana, Sianti Dewi, Niluh Suwasanti


Background: There are physiological changes during pregnancy, one of which is an increase in mother’s nutritional needs, which is protein. The most abundant plasma protein component is albumin; hypoalbuminemia is serum albumin levels below the normal values, which it can occur due to malnutrition, inflammation, kidney or liver damage where albumin is synthesized. Good nutritional status in pregnant women can prevent Low Birth Weight (LBW), while hypoalbuminemia in pregnant women can increase the risk of LBW. LBW is neonatal birth weight <2500 grams that can cause neonatal death and increase the risk of other diseases. LBW is a global problem, and in Indonesia LBW was also the most common cause of neonatal death in 2019 with a percentage of 35.3%. In Surabaya, there were 703 LBW cases (1.6%) in 2019; moreover, there were 15 LBW cases (1.92%) at Jagir Health Center in 2020. 

Aim: The aim of this study was to determine the association between maternal serum albumin levels and LBW. 

Method: The method used in this thesis is literature review with 10 research journals. The literatures that used in this literature review are journals with topics that related to the association between maternal serum albumin levels and neonatal birth weight. 

Result: From this literature review, there are 5 research journals conclude that there is a significant association between maternal serum albumin levels and neonatal birth weight.

Conclusion: In conclusion, there is a possible association between maternal serum albumin levels and neonatal birth weight. 

Keywords: maternal serum albumin, hypoalbuminemia, birth weight, LBW

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maternal serum albumin; hypoalbuminemia; birth weight; LBW

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Gómez-Cantarino S, Agulló-Ortuño MT, de Dios-Aguado M, Ugarte-Gurrutxaga MI, Bouzas-Mosquera C. Prevalence of hypoproteinemia and hypoalbuminemia in pregnant women from three different socioeconomic populations. Int J Environ Res Public Health. 2020;17(17):1–10.

Di Masi A, Trezza V, Leboffe L, Ascenzi P. Human plasma lipocalins and serum albumin: plasma alternative carriers? J Control Release [Internet]. 2016;228:191–205. Available from:

Anggraini S, Angraini DI, Mayasari D, Sari RDP. Pengaruh kurang energi kronik terhadap kadar albumin serum ibu hamil di Kota Bandar Lampung. Med J Lampung Univ. 2019;8:115–9.

Kemenkes RI. Profil kesehatan Indonesia tahun 2019. Kementerian Kesehatan Republik Indonesia. Kementerian Kesehatan RI; 2020.

Sema A, Tesfaye F, Belay Y, Amsalu B, Bekele D, Desalew A. Associated factors with low birth weight in Dire Dawa City, Eastern Ethiopia: A cross-sectional study. Biomed Res Int. 2019;2019:1–8.

Kandel KP, Kafle S. Risk factors associated with low birth weight among deliveries at Bharatpur Hospital. J Nepal Health Res Counc. 2017;15(2):169–73.

Anil KC, Basel PL, Singh S. Low birth weight and its associated risk factors: Health facility-based case-control study. PLoS One [Internet]. 2020;15(6 June):1–10. Available from:

Dinas Kesehatan Provinsi Jawa Timur. Profil kesehatan Provinsi Jawa Timur 2019. Profil Kesehatan Provinsi Jawa Timur. Dinas Kesehatan Provinsi Jawa Timur; 2020.

Trivedi DJ, Shindhe V, Rokhade CJ. Influence of maternal nutrition status during pregnancy on developmental outcome in first 30 days of independent neonatal life. Int J Clin Biochem Res. 2016;3(4):371–5.

Ahmadu BU, Ayodele AA, Ngadda H, Jungudu U. Correlation of maternal albumin and birth weight of babies in a Nigerian Teaching Hospital. Int J Public Heal Epidemiol. 2012;1(1):10–3.

Sultana M, Jahan N, Sultana N, Akter R. Serum copper and plasma protein status in normal pregnancy. J Bangladesh Soc Physiol. 2012;7(1):41–7.

Amosu AM, Degun AM. Impact of maternal nutrition on birth weight of babies. Biomed Res. 2014;25(1):75–8.

Chaudhry ER, Chaudhry ZR, Chaudhry SR. Correlation of maternal albumin levels with neonatal birth weight. J Islam Int Med Coll. 2017;12(2):97–100.

Hsu WY, Wu CH, Hsieh CTC, Lo HC, Lin JS, Kao MD. Low body weight gain, low white blood cell count and high serum ferritin as markers of poor nutrition and increased risk for preterm delivery. Asia Pac J Clin Nutr. 2013;22(1):90–9.

Wada Y, Ehara T, Tabata F, Komatsu Y, Izumi H, Kawakami S, et al. Maternal serum albumin redox state is associated with infant birth weight in Japanese pregnant women. Nutrients. 2021;13(6):1–12.

Sakar MN, Balsak D, Verit FF, Zebitay AG, Buyuk A, Akay E, et al. The effect of Ramadan fasting and maternal hypoalbuminaemia on neonatal anthropometric parameters and placental weight. J Obstet Gynaecol (Lahore). 2015;36(4):483–6.

Agbonlahor OJ, Emokpae MA. Levels of some essential elements in pregnant women and association with low birth weight of babies in Benin City. Pakistan J Nutr. 2016;15(6):585–9.

Prawirohardjo S. Ilmu kebidanan Sarwono Prawirohardjo. Ed Ke-4 Jakarta Yayasan Bina Pustaka Sarwono Prawirohardjo. 2016;

Agbecha A, Agbecha A, Yisa EN. Serum albumin level in second and third trimester pregnancies in Makurdi, Nigeria. Saudi J Biomed Res [Internet]. 2018;3(6):175–80. Available from:

Akirov A, Masri-Iraqi H, Atamna A, Shimon I. Low albumin levels are associated with mortality risk in hospitalized patients. Am J Med [Internet]. 2017;130(12):1465.e11-1465.e19. Available from:

Nzioka Mutua D, Mwaniki Njagi EN, Orinda G. Liver function tests in normal pregnant women. J Liver. 2018;07(02):2–5.

Kumalasari I, Tjekyan RS, Zulkarnain M. Faktor resiko dan angka kejadian Berat Badan Lahir Rendah (BBLR) di RSUP Dr. Mohammad Hoesin Palembang tahun 2014. J Ilmu Kesehat Masy. 2018;9(1365):41–52.

Hartiningrum I, Fitriyah N. Bayi Berat Lahir Rendah (BBLR) di Provinsi Jawa Timur Tahun 2012-2016. J Biometrika dan Kependud. 2019;7(2):97.

Mousa A, Naqash A, Lim S. Macronutrient and micronutrient intake during pregnancy: An overview of recent evidence. Nutrients. 2019;11(2):1–20.

Fatimah N, Utama BI, Sastri S. Hubungan antenatal care dengan kejadian bayi berat lahir rendah pada ibu aterm di RSUP Dr. M. Djamil Padang. J Kesehat Andalas. 2017;6(3):615–20.

Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med [Internet]. 2018;52(March):8–12. Available from:



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