Blood Sugar Levels With Neutrophil-Lymphocyte Ratio As a Marker of Diabetes Mellitus In Elderly

Theodora E da Silva, Ika Christine, Edith M Djaputra

Abstract


Introduction: Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels due to abnormal insulin secretion by the pancreas, insulin action, or both. Based on the Basic Health Research results in 2018, the elderly group dominates patients with diabetes mellitus. The diagnosis of diabetes mellitus requires an expensive examination that is not available in all laboratories, especially primary care facilities. Some research suggested that the neutrophil-lymphocyte ratio can be an alternative marker for establishing a diagnosis of diabetes mellitus. Purpose: To determine the correlation between blood sugar levels and lymphocyte ratio as a marker of diabetes mellitus in the elderly. Method: This study was an observational analytic study with a cross-sectional approach. Data was collected by conducting interviews, physical examinations, and laboratory examinations. Hypothesis testing in this study used the Spearman correlation test. Results: A total of 53 respondents were included in this study, with a proportion of 32 female subjects (60.4%). The mean age of respondents was 76.0 7.29 years. An insignificant correlation was obtained between fasting blood sugar levels and the ratio of neutrophil lymphocytes in the elderly (p = 0.161; r = 0.195). An insignificant correlation was found between blood glucose levels after two hours of postprandial with the neutrophil-lymphocyte ratio in the elderly (p = 0.595; r = 0.075). HbA1c level and the lymphocyte ratio in the elderly also showed a non-significant correlation (p = 0.873; r = -0.023) Conclusion: There is no significant correlation between blood sugar level and neutrophillymphocyte ratio as a marker of diabetes mellitus in the elderly.

Full Text:

PDF

References


ADA - American Diabetes Association. Diagnosis of diabetes and prediabetes. Diabetes Care. 2012;35(1):1163.

Riskesdas. Hasil Utama Riskesdas 2018 Kesehatan, Kementerian. 2018;

Rochmah W. Diabetes Meliitus Usia Lanjut. Manaj Kedokt Indones. 2007;

IDF IDF. Diabetes Atlas Seventh Edition. Vol. 7, International Diabetes Federation. 2015. 17144p.

Shiny A, Bibin YS, Shanthirani CS, Regin BS, Anjana RM, Balasubramanyam M, et al. Association of NeutrophilLymphocyte Ratio with Glucose Intolerance: An Indicator of Systemic Inflammation in Patients with Type 2 Diabetes. Diabetes Technol Ther [Internet]. 2014;16(8):52430.

Lou M, Luo P, Tang R, Peng Y, Yu S, Huang W, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015;15(1).

Sudigdo S dan SI. Dasar-Dasar Metodologi Klinis Edisi Ke-4. In: Dasar-Dasar Metodologi Klinis Edisi Ke-4. 2011.

World Health Organization. Use of glycated haemoglobin (HbA1c) in the diagnosis of diabetes mellitus: abbreviated report of a WHO consultation. Diabetes Res Clin Pract [Internet]. 2011;93(3):299309.

Perkeni. Penatalaksanaan DM Sesuai Konsensus Perkeni 2015. Perkeni. 2015;17.

Perkins BA, Ficociello LH, Roshan B, Warram JH, Krolewski AS. In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria. Kidney Int. 2010;77:5764.

Parving HH, Andersen AR, Smidt UM, Svendsen PA. Early aggressive antihypertensive treatment reduces rate of decline in kidney function in diabeticnephropathy. Lancet. 1983;1:11759.

Rudiger A, Burckhardt OA, Harpes P, Mller SA, Follath F. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J

Emerg Med. 2006;24:4514.




DOI: https://doi.org/10.33508/jwmj.v2i3.2667

Refbacks

  • There are currently no refbacks.




Creative Commons License
Journal of Widya Medika Junior is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License